Ammonia → 3-Benzyl-1,2,4-thiadiazol-5-amine

HRID 2063669ノート

反応式

HRID 2063669 の反応式
[CH2:1]([C:8]1[N:12]=[C:11](Cl)[S:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH3:14]>>[CH2:1]([C:8]1[N:12]=[C:11]([NH2:14])[S:10][N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 222AmmoniaHCID 147635213-Benzyl-5-chloro-1,2,4-thiadiazole

生成物 1

HCID 6055933-Benzyl-1,2,4-thiadiazol-5-amine

反応条件

温度
50 °C

実験手順

A mixture of 3-benzyl-5-chloro-[1,2,4]thiadiazole (105 mg, 0.5 mmol) in ammonia (2 N in MeOH, 2 ml) was heated in a pressure tube at 50° C. for 5 h. The solvents were evaporated, the residue diluted with dichloromethane, the white solid (ammonium chloride) was filtered off, the filtrate was concentrated and then purified by silica gel chromatography using dichloromethane/methanol as eluent. The title compound was obtained as a light yellow liquid (40 mg, 41%). MS ISP (m/e): 192.1 (100) [(M+H)+].

後処理

  1. customThe solvents were evaporated
  2. additionthe residue diluted with dichloromethane
  3. filtrationthe white solid (ammonium chloride) was filtered off
  4. concentrationthe filtrate was concentrated
  5. custompurified by silica gel chromatography

出典と根拠

ORDレコード
ord-627c223dfef649a5a6faf340263f78f3
出典データセット
uspto-grants-2012_10
特許番号
US08288403B2

反応ノート

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