5-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrile → 5-[1-(2-Chloro-phenyl)-1H-[1,2,4]triazol-3-ylamino]-2-(4-methyl-imidazol-1-yl)-benzonitrile

HRID 2063679ノート

反応式

HRID 2063679 の反応式
Br[C:2]1[CH:3]=[CH:4][C:5]([N:10]2[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]2)=[C:6]([CH:9]=1)[C:7]#[N:8].[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[N:23]1[CH:27]=[N:26][C:25]([NH2:28])=[N:24]1>>[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[N:23]1[CH:27]=[N:26][C:25]([NH:28][C:2]2[CH:3]=[CH:4][C:5]([N:10]3[CH:14]=[C:13]([CH3:15])[N:12]=[CH:11]3)=[C:6]([CH:9]=2)[C:7]#[N:8])=[N:24]1

参加物

3

反応物 2

HCID 669615175-bromo-2-(4-methyl-1H-imidazol-1-yl)benzonitrileHCID 673780411-(2-Chloro-phenyl)-1H-[1,2,4]triazol-3-ylamine

生成物 1

HCID 462142445-[1-(2-Chloro-phenyl)-1H-[1,2,4]triazol-3-ylamino]-2-(4-methyl-imidazol-1-yl)-benzonitrile

実験手順

Prepared in analogy to example 1b) starting with 5-bromo-2-(4-methyl-imidazol-1-yl)-benzonitrile and 1-(2-chloro-phenyl)-1H-[1,2,4]triazol-3-ylamine. The title compound was obtained as a colorless solid (Yield=27%). MS ISP (m/e): 374.3 (100) [(M+H)+].

後処理

  1. customPrepared in analogy to example 1b)

出典と根拠

ORDレコード
ord-07ca5daaaa8b41a7adeccb57c7a72719
出典データセット
uspto-grants-2012_10
特許番号
US08288403B2

反応ノート

読み込み中…