1-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole → (5-Benzyl-oxazol-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

反応式

Br[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]2)=[C:4]([O:14][CH3:15])[CH:3]=1.[CH2:16]([C:23]1[O:27][C:26]([NH2:28])=[N:25][CH:24]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:16]([C:23]1[O:27][C:26]([NH:28][C:2]2[CH:7]=[CH:6][C:5]([N:8]3[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]3)=[C:4]([O:14][CH3:15])[CH:3]=2)=[N:25][CH:24]=1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

参加物

反応物 2

HCID 534156611-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole

HCID 600275265-Benzyloxazol-2-amine

生成物 1

HCID 59324069(5-Benzyl-oxazol-2-yl)-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine

実験手順

Prepared in analogy to example 43 starting with 1-(4-bromo-2-methoxy-phenyl)-4-methyl-1H-imidazole and 5-benzyl-oxazol-2-ylamine. The title compound was obtained as a yellow solid (Yield=22%). MS ISP (m/e): 361.3 (100) [(M+H)+].

出典と根拠

ORDレコード: ord-cb77a1404ce64830867ff9650863be7c
出典データセット: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08288403B2

反応ノート

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