1-[3-(trifluoromethyl)benzyl]-1H-1,2,4-triazol-3-amine → HCID 46214070、化合物

反応式

Br[C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]2)=[C:4]([O:14][CH3:15])[CH:3]=1.[F:16][C:17]([F:32])([F:31])[C:18]1[CH:19]=[C:20]([CH:28]=[CH:29][CH:30]=1)[CH2:21][N:22]1[CH:26]=[N:25][C:24]([NH2:27])=[N:23]1>>[CH3:15][O:14][C:4]1[CH:3]=[C:2]([NH:27][C:24]2[N:25]=[CH:26][N:22]([CH2:21][C:20]3[CH:28]=[CH:29][CH:30]=[C:18]([C:17]([F:32])([F:16])[F:31])[CH:19]=3)[N:23]=2)[CH:7]=[CH:6][C:5]=1[N:8]1[CH:12]=[C:11]([CH3:13])[N:10]=[CH:9]1

参加物

反応物 2

HCID 70193291-[3-(trifluoromethyl)benzyl]-1H-1,2,4-triazol-3-amine

HCID 534156611-(4-bromo-2-methoxyphenyl)-4-methyl-1H-imidazole

生成物 1

HCID 46214070HCID 46214070、化合物

実験手順

Prepared in analogy to example 43 starting with 1-(4-bromo-2-methoxy-phenyl)-4-methyl-1H-imidazole and 1-(3-trifluoromethyl-benzyl)-1H-[1,2,4]triazol-3-ylamine. The title compound was obtained as a light yellow solid (Yield=63%). MS ISP (m/e): 429.3 (100) [(M+H)+].

出典と根拠

ORDレコード: ord-463f1f4ab00a4371b86b5b203cb68000
出典データセット: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08288403B2

反応ノート

読み込み中…