Ethyl vinyl ether → 4-[1-(1-Ethoxy-ethoxy)-2-phenylethyl]cyclohexanone

HRID 2063718ノート

反応式

HRID 2063718 の反応式
[CH:1]([O:3][CH2:4][CH3:5])=[CH2:2].S(C1C=CC(C)=CC=1)([O-])(=O)=O.[NH+]1C=CC=CC=1.[OH:23][CH:24]([CH:32]1[CH2:37][CH2:36][C:35](=[O:38])[CH2:34][CH2:33]1)[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>C(Cl)Cl>[CH2:1]([O:3][CH:4]([O:23][CH:24]([CH:32]1[CH2:33][CH2:34][C:35](=[O:38])[CH2:36][CH2:37]1)[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH3:5])[CH3:2]

参加物

5

反応物 3

HCID 8023Ethyl vinyl etherHCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 214336324-(1-Hydroxy-2-phenylethyl)cyclohexanone

生成物 1

HCID 668875294-[1-(1-Ethoxy-ethoxy)-2-phenylethyl]cyclohexanone

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

Ethyl vinyl ether (998 mg, 1.32 ml, 13.8 mmol) and pyridinium tosylate (44 mg, 0.17 mmol) were added to a solution of 4-(1-hydroxy-2-phenylethyl)cyclohexanone (2.52 g, 11.5 mmol) in anhydrous methylene chloride (50 ml) and the mixture was stirred at room temperature overnight. Methylene chloride (20 ml) was added to the mixture and the mixture was washed with water, 5% sodium bicarbonate solution and sodium chloride solution (50 ml of each). The combined organic phases were dried with sodium sulfate and concentrated i. vac.

後処理

  1. washthe mixture was washed with water, 5% sodium bicarbonate solution and sodium chloride solution (50 ml of each)
  2. dry with materialThe combined organic phases were dried with sodium sulfate
  3. concentrationconcentrated i

出典と根拠

ORDレコード
ord-8c79fd8dea9c466884db519ac85f7bf5
出典データセット
uspto-grants-2012_10
特許番号
US08288406B2

反応ノート

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