Hydrochloric Acid → 5-Morpholinopicolinic acid

HRID 2064240ノート

反応式

HRID 2064240 の反応式
N1([C:7]([C:9]2[N:14]=[CH:13][C:12]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)=[CH:11][CH:10]=2)=[O:8])CCCCC1.Cl.[OH-:22].[K+]>>[O:18]1[CH2:19][CH2:20][N:15]([C:12]2[CH:11]=[CH:10][C:9]([C:7]([OH:8])=[O:22])=[N:14][CH:13]=2)[CH2:16][CH2:17]1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 671512274-[6-(Piperidin-1-ylcarbonyl)pyridin-3-yl]morpholine

生成物 1

HCID 582525805-Morpholinopicolinic acid収率 71%

実験手順

25% KOH (100 mL) was added to 4-[6-(piperidin-1-ylcarbonyl)pyridin-3-yl]morpholine (18.3 g), and the mixture was refluxed and then neutralized with HCl. The solution was evaporated in vacuum, and the product was extracted with hot isopropanol to give the title compound (yield 71%, 11.5 g). +ESI MS (M+H) 209.7; 1H NMR (400 MHz, DMSO-d6) δ ppm 8.34 (br. s., 1H), 8.03 (d, 1H), 7.65 (dd, 1H), 3.75 (br. s., 4H), 3.40 (br. s., 4H).

後処理

  1. temperaturethe mixture was refluxed
  2. customThe solution was evaporated in vacuum
  3. extractionthe product was extracted with hot isopropanol

出典と根拠

ORDレコード
ord-5d5fcc09e7bf492e851e776f5e41c8b3
出典データセット
uspto-grants-2012_10
特許番号
US08288405B2

反応ノート

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