MTBE methanol → 4-{(4S)-6-methyl-2,5-dioxo-1-[3-(trifluoromethyl)phenyl]-2,3,4,5,6,7-hexahydro-1H-pyrrolo[3,4-d]pyrimidin-4-yl}-3-(methylsulfonyl)benzonitrile

反応式

CC(OC)(C)C.[CH3:7][OH:8].[C:9]([C:11]1[CH:16]=[CH:15][C:14]([C@@H:17]2[C:22](C#N)=[C:21]([CH3:25])[N:20]([C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=3)C(=O)[N:18]2S(C2CC2)(=O)=O)=[C:13]([S:43]([CH3:46])(=[O:45])=[O:44])[CH:12]=1)#[N:10].[CH3:47][OH:48].[C:49](#[N:51])C.CC(OC)(C)C>>[CH3:49][N:51]1[C:7](=[O:8])[C:22]2[C@@H:17]([C:14]3[CH:15]=[CH:16][C:11]([C:9]#[N:10])=[CH:12][C:13]=3[S:43]([CH3:46])(=[O:45])=[O:44])[NH:18][C:47](=[O:48])[N:20]([C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=3)[C:21]=2[CH2:25]1