2-Chloro-6-(trifluoromethyl)aniline → 4-(2-Chloro-6-(trifluoromethyl)phenylamino)-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one
反応式
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]([F:12])([F:11])[F:10])[C:3]=1[NH2:4].Cl[C:14]1[C:23]2[C:18](=[C:19]([O:26][CH:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)[C:20]([O:24][CH3:25])=[CH:21][CH:22]=2)[O:17][C:16](=[O:32])[CH:15]=1>>[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]([F:11])([F:10])[F:12])[C:3]=1[NH:4][C:14]1[C:23]2[C:18](=[C:19]([O:26][CH:27]3[CH2:31][CH2:30][CH2:29][CH2:28]3)[C:20]([O:24][CH3:25])=[CH:21][CH:22]=2)[O:17][C:16](=[O:32])[CH:15]=1参加物
3
実験手順
The title compound was prepared from 2-chloro-6-(trifluoromethyl)aniline and 4-chloro-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one following the procedure outlined in Example 16. 1H NMR (400 MHz, DMSO-d6): δ 9.34 (s, 1H), 8.05 (d, 1H), 7.93 (d, 1H), 7.91 (d, 1H), 7.71 (t, 1H), 7.18 (d, 1H), 4.82 (m, 1H), 4.29 (s, 1H), 3.90 (s, 3H), 1.90-1.45 (m, 8H); MS (ESI): 453.9.
出典と根拠
- ORDレコード
- ord-d86b8f5612824bd7a47af2d076f290a2
- 出典データセット
- uspto-grants-2010_06