3-Hydroxyanthranilic Acid → 1,3-Benzoxazole-4-carboxylic acid
反応式
[NH2:1][C:2]1[C:10]([OH:11])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH:12](OC)(OC)OC>>[O:11]1[C:10]2=[CH:9][CH:8]=[CH:7][C:3]([C:4]([OH:6])=[O:5])=[C:2]2[N:1]=[CH:12]1参加物
3
実験手順
A solution of 2-amino-3-hydroxy-benzoic acid (13.1 mmol) in trimethyl orthoformate (20.0 mL) is refluxed for 4 h, cooled to RT and concentrated in vacuo to give a crude product which is used without further purification. LC-MS: tR=0.66 min; [M+H]+=164.1.
後処理
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-ba430ae285494c18bda18b0409b7e5f0
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08288435B2
反応ノート
読み込み中…