Hydrochloric Acid → N-[(1S,3S,5S)-2-Azabicyclo[3.1.0]hex-3-ylmethyl]-2,2,2-trifluoroacetamide
反応式
Cl.C(OC([N:9]1[C@H:14]([CH2:15][NH:16][C:17](=[O:22])[C:18]([F:21])([F:20])[F:19])[CH2:13][C@H:12]2[C@@H:10]1[CH2:11]2)=O)(C)(C)C>O1CCOCC1>[C@H:10]12[CH2:11][C@H:12]1[CH2:13][C@@H:14]([CH2:15][NH:16][C:17](=[O:22])[C:18]([F:20])([F:21])[F:19])[NH:9]2参加物
4
実験手順
A solution of HCl in dioxane (4 M, 25 mL) is added to a solution of (1S,3S,5S)-3-[(2,2,2-trifluoro-acetylamino)-methyl]-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester (5.74 mmol) in dioxane (25 mL). After 2 h the solvents are removed in vacuo to give the desired product as a white solid which is used without further purification in the next step. LC-MS (acidic): tR=0.30 min; [M+H]+=209.0.
後処理
- customAfter 2 h the solvents are removed in vacuo
出典と根拠
- ORDレコード
- ord-d407d40abc0c427a94240c40e277560f
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08288435B2
反応ノート
読み込み中…