1,4-Dioxane → ethyl (3S)-1-(2-fluoro-4-pyridin-4-ylphenyl)piperidine-3-carboxylate

反応式

Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)=[CH:4][C:3]=1[F:14].Cl.[NH:16]1[CH2:21][CH2:20][CH2:19][C@H:18]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:17]1.CC(C)([O-])C.[Na+].C(P(C(C)(C)C)C1C=CC=CC=1C1C=CC=CC=1)(C)(C)C.O1CCOCC1>C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[F:14][C:3]1[CH:4]=[C:5]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=2)[CH:6]=[CH:7][C:2]=1[N:16]1[CH2:21][CH2:20][CH2:19][C@H:18]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:17]1