Triethylamine → HCID 178453336、化合物

HRID 2065564ノート

反応式

HRID 2065564 の反応式
C(OC([N:8]1[CH:12]=[C:11]([CH2:13][CH2:14][NH:15][C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[N:10]=[CH:9]1)=O)(C)(C)C.C(N(CC)CC)C>CO>[C:19]([O:18][C:16](=[O:17])[NH:15][CH2:14][CH2:13][C:11]1[N:10]=[CH:9][NH:8][CH:12]=1)([CH3:22])([CH3:20])[CH3:21]

参加物

4

反応物 2

HCID 8471TriethylamineHCID 819122tert-butyl 4-{2-[(tert-butoxycarbonyl)amino]ethyl}-1H-imidazole-1-carboxylate

生成物 1

HCID 178453336HCID 178453336、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To 4-(2-tert-Butoxycarbonylamino-ethyl)-imidazole-1-carboxylic acid tert-butyl ester, were added 100 mL of methanol and 800 mL (5.73 mol) of triethylamine. The reaction mixture was allowed to stir at room temperature for four days and concentrated to oil. To the residue were added 40 mL of ether and 80 mL of hexane. This mixture was allowed to stand at room temperature resulting in precipitation of product, as a white solid, which were collected. The yield was 1.7 g (8.0 mmol, 40%) (LC/MS M+H 212.1).

後処理

  1. concentrationconcentrated to oil
  2. additionTo the residue were added 40 mL of ether and 80 mL of hexane
  3. customto stand at room temperature
  4. customresulting in precipitation of product, as a white solid, which
  5. customwere collected

出典と根拠

ORDレコード
ord-11d6acfbcd59412da06441c9971063a1
出典データセット
uspto-grants-2012_10
特許番号
US08288544B2

反応ノート

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