関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | L-Phenylalanine | HCID 6140 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2,6-Dichloroquinoline-3-carboxylic acid | HCID 24266068 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-((S)-1-Carboxy-2-phenyl-ethylamino)-6-chloro-quinoline-3-carboxylic acid | HCID 45109874 | 57% |
反応手順
A mixture of 2,6-dichloroquinoline-3-carboxylic acid (243 mg, 1 mmol), L-phenylalanine (330 mg, 2 mmol) and potassium carbonate (415 mg, 3 mmol) in water (3 mL) is stirred for 24 h at 135° C. in closed reaction vial. After cooling, the reaction mixture is acidified by addition of 2N HCl, and the precipitated solid is collected on filter, washed with water and recrystallized from DMF-water to give the title compound (211 mg, 57%) as yellow needles.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08288549B2 |
|---|
| 出典データセット | uspto-grants-2012_10 |
|---|
| ORD ID | ord-2c16d953b3ca48a082211eb59611e8e7 |
|---|
| 出典メモ | uspto-grants-2012_10 |
|---|
