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Dl-Tryptophan → 2-[1-Carboxy-2-(1H-indol-3-yl)-ethylamino]-6-chloro-quinoline-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dl-Tryptophan | HCID 1148 | — |
| 反応物 | 2,6-Dichloroquinoline-3-carboxylic acid | HCID 24266068 | — |
| 生成物 | 2-[1-Carboxy-2-(1H-indol-3-yl)-ethylamino]-6-chloro-quinoline-3-carboxylic acid | HCID 45256702 | 42% |
反応手順
In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with DL-tryptophan to provide the title compound in 42% yield as yellow needles (recrystallization from isopropanol).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08288549B2 |
| 出典データセット | uspto-grants-2012_10 |
| ORD ID | ord-73afbdec5a5642eb980ff6e173105de3 |
| 出典メモ | uspto-grants-2012_10 |