化工社化工社 化学情報印刷レポート · 研究参考用
DL-norvaline → 2-(1-Carboxy-butylamino)-6-chloro-quinoline-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | DL-norvaline | HCID 824 | — |
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | 2,6-Dichloroquinoline-3-carboxylic acid | HCID 24266068 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-(1-Carboxy-butylamino)-6-chloro-quinoline-3-carboxylic acid | HCID 45256873 | 15% |
反応手順
In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with DL-2-aminopentanoic acid to provide the title compound in 15% yield as yellow needles (flash chromatography on SiO2, eluent MeCN, H2O, AcOH-20, 1, 0.3).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08288549B2 |
| 出典データセット | uspto-grants-2012_10 |
| ORD ID | ord-fe506c4b218f493383546404080c7ff9 |
| 出典メモ | uspto-grants-2012_10 |