Hydrochloric Acid → HCID 44474092、化合物
反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[CH3:21])[CH:10]([C:22]([N:24]2[CH2:29][CH2:28][N:27]([C:30]3[CH:35]=[C:34]([CH3:36])[CH:33]=[CH:32][C:31]=3[CH3:37])[CH2:26][CH2:25]2)=[O:23])[CH2:9]1)=O)(C)(C)C.[ClH:38]>C(O)C>[ClH:38].[CH3:37][C:31]1[CH:32]=[CH:33][C:34]([CH3:36])=[CH:35][C:30]=1[N:27]1[CH2:28][CH2:29][N:24]([C:22]([CH:10]2[CH2:9][NH:8][CH2:13][CH2:12][N:11]2[C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[CH3:21])=[O:23])[CH2:25][CH2:26]1参加物
4
実験手順
To a solution of 3-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-4-(4-fluoro-2-methyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester (133 mg) in ethanol (5 mL) was added a saturated solution of hydrogen chloride in ethanol (1 mL). The mixture was stirred at room temperature for 2 h, and was concentrated to give [4-(2,5-dimethyl-phenyl)-piperazin-1-yl]-[1-(4-fluoro-2-methyl-phenyl)-piperazin-2-yl]-methanone hydrochloride as crude white solid, MS: 411.5 ([M+H]+).