(3R,4R)-1-(tert-Butoxycarbonyl)-4-phenylpiperidine-3-carboxylic acid → 1-(2,5-Xylyl)piperazine
反応式
C(OC(N1CC[C@@H](C2C=CC=CC=2)[C@@H](C(O)=O)C1)=O)(C)(C)C.C(OC(N1CC[C@@H](C2C=CC=CC=2)[C@@H](C([N:44]2[CH2:49][CH2:48][N:47]([C:50]3[CH:55]=[C:54]([CH3:56])[CH:53]=[CH:52][C:51]=3[CH3:57])[CH2:46][CH2:45]2)=O)C1)=O)(C)(C)C>>[CH3:57][C:51]1[CH:52]=[CH:53][C:54]([CH3:56])=[CH:55][C:50]=1[N:47]1[CH2:46][CH2:45][NH:44][CH2:49][CH2:48]1参加物
3
実験手順
In analogy to example 1, step 1, from (3R,4R)-4-phenyl-piperidine-1,3-dicarboxylic acid 1-tert-butyl ester (CAS Reg. No.: [197900-84-8]) and 1-(2,5-dimethylphenyl)piperazine was prepared (3R,4R)-3-[4-(2,5-dimethyl-phenyl)-piperazine-1-carbonyl]-4-phenyl-piperidine-1-carboxylic acid tert-butyl ester as a white foam, MS: 478.27 ([M+H])+.
出典と根拠
- ORDレコード
- ord-535c603c3f494067acbbd64de35f4119
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08288541B2