3-Pyridinecarboxaldehyde → HCID 68959247、化合物

HRID 2065850ノート

反応式

HRID 2065850 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH:7]=[O:8])[CH:2]=1.[OH-].[K+].[N+:11]([CH2:13][C:14]([N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1)=[O:15])#[C-:12]>CO>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C@@H:7]2[O:8][CH:12]=[N:11][C@H:13]2[C:14]([N:16]2[CH2:17][CH2:18][O:19][CH2:20][CH2:21]2)=[O:15])[CH:2]=1

参加物

5

反応物 3

HCID 103713-PyridinecarboxaldehydeHCID 14797Potassium HydroxideHCID 6455475Morpholine, 4-(isocyanoacetyl)-2 回

生成物 1

HCID 68959247HCID 68959247、化合物収率 72.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

SLA 09050A was prepared in accordance with method D using pyridine-3-carbaldehyde (0.65 mL, 4.86 mmol), KOH (0.273 mg, 4.86 mmol) in methanol (10 mL) and 2-isocyano-1-morpholinoethanone SLA 07118 (0.75 g, 4.86 mmol). The solution was stirred for 20 h at 0° C. After work-up (without any further purification), evaporation and drying trans-(4,5-dihydro-5-(pyridin-3-yl)oxazol-4-yl)(morpholino)methanone SLA 09050A was obtained as a yellow solid (0.92 g, 72.5% yield).

後処理

  1. customAfter work-up (without any further purification),
  2. customevaporation
  3. dry with materialdrying trans-(4,5-dihydro-5-(pyridin-3-yl)oxazol-4-yl)(morpholino)methanone SLA 09050A

出典と根拠

ORDレコード
ord-69082d3dae3644c18931d4f691f76174
出典データセット
uspto-grants-2012_10
特許番号
US08288556B2

反応ノート

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