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4-Nitrobenzyl bromide → 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(4-nitrobenzyloxy)-2H-chromen-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitrobenzyl bromide | HCID 66011 | — |
| 反応物 | 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one | HCID 24849570 | — |
| 生成物 | 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(4-nitrobenzyloxy)-2H-chromen-2-one | HCID 24849621 | — |
反応手順
The title compound was prepared from 1-(bromomethyl)-4-nitrobenzene and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedure outlined in Example 25. 1H NMR (400 MHz, DMSO-d6): δ 9.55 (s, 1H), 8.81 (s, 2H), 8.25 (d, 2H), 7.99 (d, 1H), 7.80 (d, 2H), 7.25 (d, 1H), 5.20 (s, 2H), 4.66 (s, 1H), 3.93 (s, 3H); MS (ESI): 487.8.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745646B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-7da20564ac7f4eb4b9839fae9834f8f1 |
| 出典メモ | uspto-grants-2010_06 |