(R)-Tetrahydro-1H-oxazolo[3,4-a]pyrazin-3(5H)-one → HCID 58117061、化合物
反応式
[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:15]C4(CCN(C)CC4)[CH2:13]3)=[CH:8][C:6]=2[N:7]=1.[CH2:28]1[C@H:32]2CNC[CH2:36][N:31]2[C:30](=[O:37])[O:29]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:22]2[CH2:23][CH2:24][O:25][CH2:26][CH2:27]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:15][CH2:36][N:31]4[C:30](=[O:37])[O:29][CH2:28][C@H:32]4[CH2:13]3)=[CH:8][C:6]=2[N:7]=1参加物
3
実験手順
Prepared according to the method used in the preparation of 2-chloro-6-(7-methyl-2,7-diaza-spiro[3.5]non-2-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine using (R)-hexahydro-oxazolo[3,4-a]pyrazin-3-one in place of 7-methyl-2,7-diaza-spiro[3.5]nonane. The title compound was obtained as a white solid (71 mg, 50%).
後処理
- customPrepared