Octahydropiperazino[2,1-c]morpholine → (+/-)-8-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-octahydro-pyrazino[2,1-c][1,4]oxazine
反応式
[Cl:1][C:2]1[N:3]=[C:4]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][NH:15][C:14](=O)[CH2:13]3)=[CH:8][C:6]=2[N:7]=1.[CH2:25]1[CH:30]2CNCCN2C[CH2:27][O:26]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:19]2[CH2:24][CH2:23][O:22][CH2:21][CH2:20]2)[C:5]2[S:10][C:9]([CH2:11][N:12]3[CH2:17][CH2:16][N:15]4[CH:14]([CH2:27][O:26][CH2:25][CH2:30]4)[CH2:13]3)=[CH:8][C:6]=2[N:7]=1参加物
3
実験手順
Prepared according to the method used in the preparation of 4-(2-chloro-4-morpholin-4-yl-thieno[3,2-d]-pyrimidin-6-ylmethyl)-piperazin-2-one using octahydro-pyrazino[2,1-c][1,4]oxazine in place of piperazin-2-one. The title compound was obtained as a white solid (79 mg, 64%).
後処理
- customPrepared