2-Chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde → 4-(2-Chloro-6-((4-(tetrahydrofuran-3-yl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine
反応式
[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH:11]=O)=[CH:8][C:6]=2[N:7]=1.[O:19]1[CH2:23][CH2:22][CH:21]([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:20]1>>[Cl:1][C:2]1[N:3]=[C:4]([N:13]2[CH2:18][CH2:17][O:16][CH2:15][CH2:14]2)[C:5]2[S:10][C:9]([CH2:11][N:27]3[CH2:26][CH2:25][N:24]([CH:21]4[CH2:22][CH2:23][O:19][CH2:20]4)[CH2:29][CH2:28]3)=[CH:8][C:6]=2[N:7]=1参加物
3
実験手順
Prepared from 2-chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidine-6-carbaldehyde and 1-(tetrahydro-furan-3-yl-piperazine under reductive amination conditions described in Reference Example 39, to give after silica chromatography, the title compound as a white solid (217 mg, 60%).
後処理
- customto give after silica chromatography