Hydrochloric Acid → HCID 58095730、化合物
反応式
Cl.[CH3:2][C:3]1[N:4]=[C:5]([NH:20]C(=O)C)[S:6][C:7]=1[C:8]1[N:9]=[C:10]([C:13]2([C:16]([F:19])([F:18])[F:17])[CH2:15][CH2:14]2)[S:11][CH:12]=1>CCO>[CH3:2][C:3]1[N:4]=[C:5]([NH2:20])[S:6][C:7]=1[C:8]1[N:9]=[C:10]([C:13]2([C:16]([F:19])([F:18])[F:17])[CH2:14][CH2:15]2)[S:11][CH:12]=1参加物
4
実験手順
HCl (1.17 g 32% aqueous solution) was added to a solution of N-[4′-methyl-2-(1-trifluoromethyl-cyclopropyl)-[4,5′]bithiazolyl-2′-yl]-acetamide (Step 10.3) (0.18 g) in EtOH (10 mL) and the reaction mixture heated at reflux for 7 h. The cooled reaction mixture was partitioned between EtOAc and aqueous NaHCO3 solution, the organic layers dried over Na2SO4 and evaporated to give the title compound. MS (ESI): positive 306.1 (M+H), negative 304.1 (M−H).
後処理
- temperaturethe reaction mixture heated
- temperatureat reflux for 7 h
- customThe cooled reaction mixture
- customwas partitioned between EtOAc and aqueous NaHCO3 solution
- dry with materialthe organic layers dried over Na2SO4
- customevaporated
出典と根拠
- ORDレコード
- ord-6ba4be43f7d246b28a856a1349659a3a
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08293753B2
反応ノート
読み込み中…