Acetic Anhydride → N-Benzyl-N-((E)-but-1-enyl)-acetamide

HRID 2066884ノート

反応式

HRID 2066884 の反応式
[CH2:1]([NH:8]/[CH:9]=[CH:10]/[CH2:11][CH3:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:20](OC(=O)C)(=[O:22])[CH3:21]>C1(C)C=CC=CC=1>[CH2:1]([N:8](/[CH:9]=[CH:10]/[CH2:11][CH3:12])[C:20](=[O:22])[CH3:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 15360338Benzyl-((E)-but-1-enyl)-amine

生成物 1

HCID 13494620N-Benzyl-N-((E)-but-1-enyl)-acetamide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
0 °C

実験手順

To 62a (3.22 g, 20 mmol) in 10 mL of toluene, was added triethylamine (2.79 mL, 20 mmol). The mixture was cooled to 0° C. and acetic anhydride (1.89 mL, 20 mmol) was added dropwise. The mixture was warmed to room temperature and stirred overnight. It was then concentrated on high vacuum to give crude 62b.

後処理

  1. temperatureThe mixture was warmed to room temperature
  2. concentrationIt was then concentrated on high vacuum

出典と根拠

ORDレコード
ord-cd85b76f62644e16b5d6b84171cc7b09
出典データセット
uspto-grants-2012_10
特許番号
US08293729B2

反応ノート

読み込み中…