Hydrochloric Acid → (Tetrahydro-2H-pyran-3-yl)hydrazine hydrochloride
反応式
[O:1]1[CH2:6][CH2:5][CH2:4][CH:3]([NH:7][NH:8]C(OC(C)(C)C)=O)[CH2:2]1.C(OCC)(=O)C.[ClH:22]>ClCCl>[ClH:22].[O:1]1[CH2:6][CH2:5][CH2:4][CH:3]([NH:7][NH2:8])[CH2:2]1参加物
5
実験手順
(±)-tert-Butyl 2-(tetrahydro-2H-pyran-3-yl)hydrazinecarboxylate (216 mg, 1.00 mmol) was dissolved in dichloromethane (10 mL) and ethyl acetate (10 mL) and cooled to 0° C. The mixture was saturated with gaseous hydrogen chloride, warmed to ambient temperature and stirred for 1 hour. The mixture was concentrated in vacuo and the residue was concentrated with toluene (2×20 mL) to afford the titled compound.
後処理
- concentrationThe mixture was concentrated in vacuo
- concentrationthe residue was concentrated with toluene (2×20 mL)
出典と根拠
- ORDレコード
- ord-10119f9c75114a698d98f03937e9b015
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08293744B2
反応ノート
読み込み中…