関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-(1,2,3-Thiadiazol-4-Yl)Phenol | HCID 2796860 | — |
| 反応物 | 4,6-Dichloro-5-(1,3-dioxolan-2-yl)pyrimidine | HCID 59594440 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Chloro-5-[1,3]dioxolan-2-yl-6-(4-[1,2,3]thiadiazol-4-yl-phenoxy)-pyrimidine | HCID 86607980 | — |
反応手順
To a mixture of 4,6-dichloro-5-[1,3]dioxolan-2-yl-pyrimidine (100.0 mg, 0.45 mmol) and added Potassium Carbonate (80.62 mg, 0.45 mmol) in DMF (5 mL) cooled to 0° C. was added a solution of 4-[1,2,3]-thiadiazol-4-yl-phenol (DMF) drop wise. The resulting mixture was stirred at room temperature for 30 minutes to give 4-chloro-5-[1,3]dioxolan-2-yl-6-(4-[1,2,3]thiadiazol-4-yl-phenoxy)-pyrimidine. LCMS (ESI) for C15H11ClN4O3S: m/z 362.9 (M+H+, 100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08293751B2 |
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| 出典データセット | uspto-grants-2012_10 |
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| ORD ID | ord-2f0275702e394a64b5c2a8bb1d5aeedd |
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| 出典メモ | uspto-grants-2012_10 |
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