Potassium Carbonate → 4-(2,5-Difluoro-phenylamino)-6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-pyrimidine-5-carbonitrile

HRID 2067136ノート

反応式

HRID 2067136 の反応式
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[F:11][C:12]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:13]=1[NH2:14].C([O-])([O-])=O.[K+].[K+].[CH:26]([C:29]1[N:33]=[C:32]([CH:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)[O:31][N:30]=1)([CH3:28])[CH3:27]>CN(C=O)C.O.CCOC(C)=O>[F:11][C:12]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:13]=1[NH:14][C:2]1[C:7]([C:8]#[N:9])=[C:6]([N:37]2[CH2:36][CH2:35][CH:34]([C:32]3[O:31][N:30]=[C:29]([CH:26]([CH3:28])[CH3:27])[N:33]=3)[CH2:39][CH2:38]2)[N:5]=[CH:4][N:3]=1

参加物

8

反応物 4

HCID 11430Potassium Carbonate2 回HCID 677752,5-DifluoroanilineHCID 5993714,6-Dichloropyrimidine-5-carbonitrileHCID 242088454-(3-(Propan-2-yl)-1,2,4-oxadiazol-5-yl)piperidine

生成物 1

HCID 582164154-(2,5-Difluoro-phenylamino)-6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-pyrimidine-5-carbonitrile

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 4,6-Dichloro-pyrimidine-5-carbonitrile (254 mg, 1.47 mmol) and 2,5-difluoroaniline (190 mg, 1.47 mmol) in DMF (3 mL) at 0° C. was added K2CO3 (203 mg, 1.47 mmol). The completion of the reaction was monitored by TLC (EtOAc:Hex=1:1, Rf=0.90). After the reaction was complete, 4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidine (340 mg, 1.47 mmol) and K2CO3 (406 mg, 2.94 mmol) were added at 0° C. The reaction was warmed to rt and stirred for 30 min. The reaction was heated to 40° C. and maintained for 1 h. The reaction was cooled to rt, poured in to H2O (50 mL) and extracted with EtOAc (50 mL, two times). The EtOAc was dried over MgSO2 and concentrated under vacuum. The crude product was purified over SiO2 (EtoAc:Hex=1:1, Rf=0.44) to afford the desired Compound B131 (465 mg; 71.1%). 1H-NMR (DMSO-d6): 9.32 (1H, s), 8.19 (1H, s), 7.40˜7.08 (3H, m), 4.54 (2H, m), 3.48˜3.32 (4H, m), 3.07˜3.01 (2H, m), 2.18˜2.14 (2H, b), 1.96˜1.86 (2H, m), 1.27 (6H, d) ppm. LCMS: 426.43.

後処理

  1. temperatureThe reaction was heated to 40° C.
  2. temperaturemaintained for 1 h
  3. temperatureThe reaction was cooled to rt
  4. extractionextracted with EtOAc (50 mL, two times)
  5. dry with materialThe EtOAc was dried over MgSO2
  6. concentrationconcentrated under vacuum
  7. customThe crude product was purified over SiO2 (EtoAc:Hex=1:1, Rf=0.44)

出典と根拠

ORDレコード
ord-dcbe55ad45b14f42a3a04b0c3c6d8850
出典データセット
uspto-grants-2012_10
特許番号
US08293751B2

反応ノート

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