HCID 11449562、化合物 → HCID 72806257、化合物
反応式
[CH3:1][N:2]([CH3:22])[C:3]([CH2:5][CH2:6][CH2:7][C:8]#[C:9][C:10]1[CH:11]=[C:12]([CH:19]=[CH:20][CH:21]=1)[C:13]([NH:15][CH2:16][CH2:17][F:18])=[O:14])=[O:4]>[Ni]>[CH3:22][N:2]([CH3:1])[C:3]([CH2:5][CH2:6][CH2:7][CH:8]=[CH:9][C:10]1[CH:11]=[C:12]([CH:19]=[CH:20][CH:21]=1)[C:13]([NH:15][CH2:16][CH2:17][F:18])=[O:14])=[O:4]参加物
3
実験手順
Hydrogenation of 3-(5-dimethylcarbamoyl-pent-1-ynyl)-N-(2-fluoro-ethyl)benzamide (26) (0.040 g, 0.13 mmol) using BER/Ni catalyst gave 40% 28, and 55% of starting material. The mixture was separated by reverse-phase HPLC chromatography (30% acetonitrile/70% water 20 min isocratic program) to give 3-(5-dimethylcarbamoyl-pent-1-enyl)-N-(2-fluoro-ethyl)-benzamide 28 (5 mg).
出典と根拠
- ORDレコード
- ord-d48104cf7a1b4be6be406a77acba69d5
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08293796B2
反応ノート
読み込み中…