Potassium Carbonate → HCID 58677657、化合物

HRID 2067191ノート

反応式

HRID 2067191 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[C:26][Si](C)(C)C)[CH:22]=[CH:21][C:20]=1[CH3:31])=[O:18].C([O-])([O-])=O.[K+].[K+].CCOC(C)=O.O>CO>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[CH:26])[CH:22]=[CH:21][C:20]=1[CH3:31])=[O:18]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 22728543Water ethylacetateHCID 67314552HCID 67314552、化合物

生成物 1

HCID 58677657HCID 58677657、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of compound 406 (426 mg, 0.94 mmol) and K2CO3 (195 mg, 1.41 mmol) in methanol (4.0 mL) were stirred at RT for 5 h. The reaction mixture was poured into a mixture of EtOAc/water. The organic phase was washed with water, brine and then dried (MgSO4), filtered and concentrated in vacuo to give the crude title compound. The product was used without any further purification.

後処理

  1. washThe organic phase was washed with water, brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-eb3c9c38724444e588cf6e4b06ea2a11
出典データセット
uspto-grants-2012_10
特許番号
US08293772B2

反応ノート

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