HCID 11548643、化合物 → [2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-{5-[1-(3-hydroxy-propyl)-1H-[1,2,3]triazol-4-yl]-2-methyl-phenyl}-methanone

HRID 2067196ノート

反応式

HRID 2067196 の反応式
ClC1C=C(NC2C=CC(F)=CC=2F)C=CC=1C(C1C=C(C2N=NN(CCO)C=2)C=CC=1C)=O.[Cl:34][C:35]1[CH:40]=[C:39]([NH:41][C:42]2[CH:47]=[CH:46][C:45]([F:48])=[CH:44][C:43]=2[F:49])[CH:38]=[CH:37][C:36]=1[C:50]([C:52]1[CH:57]=[C:56]([C:58]2[N:59]=[N:60][N:61]([CH2:63][CH2:64][CH2:65][O:66]C3CCCCO3)[CH:62]=2)[CH:55]=[CH:54][C:53]=1[CH3:73])=[O:51]>>[Cl:34][C:35]1[CH:40]=[C:39]([NH:41][C:42]2[CH:47]=[CH:46][C:45]([F:48])=[CH:44][C:43]=2[F:49])[CH:38]=[CH:37][C:36]=1[C:50]([C:52]1[CH:57]=[C:56]([C:58]2[N:59]=[N:60][N:61]([CH2:63][CH2:64][CH2:65][OH:66])[CH:62]=2)[CH:55]=[CH:54][C:53]=1[CH3:73])=[O:51]

参加物

3

反応物 2

HCID 11548643HCID 11548643、化合物HCID 11612479HCID 11612479、化合物

生成物 1

HCID 11705730[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-{5-[1-(3-hydroxy-propyl)-1H-[1,2,3]triazol-4-yl]-2-methyl-phenyl}-methanone

実験手順

The reaction was carried out similarly as described in the preparation of compound 102, using compound 103 (0.2 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 50:50 to 100:0 as the eluent to afford the title compound as colourless foam. 13C NMR (CDCl3) δ 196.1, 159.2 (dd), 155.6 (dd), 148.0, 146.9, 139.9, 137.7, 135.3, 133.8, 131.9, 129.1, 128.0, 127.9, 126.4, 124.5 (dd), 124.3 (dd), 120.3, 116.3, 112.8, 111.6 (dd), 104.9 (dd), 58.8, 47.0, 32.6, 20.2

後処理

  1. customThe crude product was purified by continuous gradient flash chromatography

出典と根拠

ORDレコード
ord-da3db75c22f348308e061f76759cc001
出典データセット
uspto-grants-2012_10
特許番号
US08293772B2

反応ノート

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