[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone → [2-Chloro-4-(4-fluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone

HRID 2067225ノート

反応式

HRID 2067225 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2F)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([I:25])[CH:22]=[CH:21][C:20]=1[CH3:26])=[O:18].NC1C=CC(C)=C(C(C2C=CC(NC3C=CC(F)=CC=3)=CC=2Cl)=O)C=1>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:10]=[CH:11][C:12]([F:15])=[CH:13][CH:14]=2)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([I:25])[CH:22]=[CH:21][C:20]=1[CH3:26])=[O:18]

参加物

3

反応物 2

HCID 67314444[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanoneHCID 68418042(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-fluoro-phenylamino)-phenyl]-methanone

生成物 1

HCID 68421852[2-Chloro-4-(4-fluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone

実験手順

The reaction was carried out similarly as described in the preparation of compound 405, using compound 429 (8.46 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 2:8 followed by 3:7 as the eluent to afford the title compound as solid.

後処理

  1. customThe crude product was purified by flash chromatography

出典と根拠

ORDレコード
ord-4621356e2f864caf9e7fbce6c832f793
出典データセット
uspto-grants-2012_10
特許番号
US08293772B2

反応ノート

読み込み中…