Trimethylsilylacetylene → HCID 68418431、化合物

HRID 2067226ノート

反応式

HRID 2067226 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2F)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[C:26][Si:27]([CH3:30])([CH3:29])[CH3:28])[CH:22]=[CH:21][C:20]=1[CH3:31])=[O:18].ClC1C=C(NC2C=CC(F)=CC=2)C=CC=1C(C1C=C(I)C=CC=1C)=O.C([Si](C)(C)C)#C>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:10]=[CH:11][C:12]([F:15])=[CH:13][CH:14]=2)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[C:26][Si:27]([CH3:28])([CH3:30])[CH3:29])[CH:22]=[CH:21][C:20]=1[CH3:31])=[O:18]

参加物

4

反応物 3

HCID 66111TrimethylsilylacetyleneHCID 67314552HCID 67314552、化合物HCID 68421852[2-Chloro-4-(4-fluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone

生成物 1

HCID 68418431HCID 68418431、化合物

実験手順

The reaction was carried out similarly as described in the preparation of compound 406, using compound 430 (7.17 mmol) and ethynyltrimethylsilane (7.17 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 1:8 as the eluent to afford the title compound as yellow solid.

後処理

  1. customThe crude product was purified by flash chromatography

出典と根拠

ORDレコード
ord-16cd4c58670c4f8ba427ad94984154f5
出典データセット
uspto-grants-2012_10
特許番号
US08293772B2

反応ノート

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