HCID 11577394、化合物 → HCID 11633801、化合物

HRID 2067229ノート

反応式

HRID 2067229 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2F)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]2[N:26]=[N:27][N:28]([CH2:30][CH2:31][OH:32])[CH:29]=2)[CH:22]=[CH:21][C:20]=1[CH3:33])=[O:18].ClC1C=C(NC2C=CC(F)=CC=2)C=CC=1C(C1C=C(C2N=NN(CCOC3CCCCO3)C=2)C=CC=1C)=O>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:10]=[CH:11][C:12]([F:15])=[CH:13][CH:14]=2)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]2[N:26]=[N:27][N:28]([CH2:30][CH2:31][OH:32])[CH:29]=2)[CH:22]=[CH:21][C:20]=1[CH3:33])=[O:18]

参加物

3

反応物 2

HCID 11577394HCID 11577394、化合物HCID 11612479HCID 11612479、化合物

生成物 1

HCID 11633801HCID 11633801、化合物

実験手順

The reaction was carried out similarly as described in the preparation of compound 102, using compound 121 (1.63 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 50:50 to 100:0 as the eluent to afford the title compound as yellow syrup.

後処理

  1. customThe crude product was purified by continuous gradient flash chromatography

出典と根拠

ORDレコード
ord-060a10055dab4aa9a2192df2b6f74f24
出典データセット
uspto-grants-2012_10
特許番号
US08293772B2

反応ノート

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