[2-Chloro-4-(3-fluoro-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanone → (5-Amino-2-methyl-phenyl)-[2-chloro-4-(3-fluoro-phenylamino)-phenyl]-methanone

HRID 2067281ノート

反応式

HRID 2067281 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:28])=[C:6]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]3[CH:22]=C[C:20]([C:23](F)([F:25])F)=[CH:19][CH:18]=3)=[CH:12][C:11]=2[Cl:27])=[O:9])[CH:7]=1.ClC1C=C(NC2C=CC=C(F)C=2)C=CC=1C(C1C=C([N+]([O-])=O)C=CC=1C)=O>>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:28])=[C:6]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][C:17]3[CH:18]=[CH:19][CH:20]=[C:23]([F:25])[CH:22]=3)=[CH:12][C:11]=2[Cl:27])=[O:9])[CH:7]=1

参加物

3

反応物 2

HCID 68417015[2-Chloro-4-(3-fluoro-phenylamino)-phenyl]-(2-methyl-5-nitro-phenyl)-methanoneHCID 68419668(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-trifluoromethyl-phenylamino)-phenyl]-methanone

生成物 1

HCID 68416513(5-Amino-2-methyl-phenyl)-[2-chloro-4-(3-fluoro-phenylamino)-phenyl]-methanone

実験手順

The reaction was carried out similarly as described in the preparation of compound 415, using compound 457 (2.25 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 1:2 as the eluent to afford the title compound as yellow foam.

後処理

  1. customThe crude product was purified by flash chromatography

出典と根拠

ORDレコード
ord-4d99f93a5dd54615ab025cdd588786af
出典データセット
uspto-grants-2012_10
特許番号
US08293772B2

反応ノート

読み込み中…