2-Chloroethyl isocyanate → HCID 20636586、化合物

反応式

[NH2:1][C:2]1[S:3][C:4](C(OCC)=O)=[C:5]([CH3:7])[N:6]=1.NC1SC=C(C)N=1.Cl[CH2:21][CH2:22][N:23]=[C:24]=[O:25]>>[CH3:7][C:5]1[N:6]=[C:2]([N:1]2[CH2:21][CH2:22][NH:23][C:24]2=[O:25])[S:3][CH:4]=1

参加物

反応物 3

HCID 160352-Chloroethyl isocyanate

HCID 741432-Amino-4-methylthiazole

HCID 343747Ethyl 2-amino-4-methylthiazole-5-carboxylate

生成物 1

HCID 20636586HCID 20636586、化合物収率 90%

実験手順

Following the procedure as described in Example 3, making variations as required to replace ethyl 2-amino-4-methylthiazole-5-carboxylate with 2-amino-4-methylthiazole to react with 2-chloroethyl isocyanate, the title compound was obtained as a colorless solid in 90% yield: 1H NMR (300 MHz, CDCl3) δ 6.41 (s, 1H), 5.79 (br s, 1H), 4.20-4.14 (m, 2H), 3.67-3.61 (m, 2H), 2.29 (s, 3H); MS (ES+) m/z 184.1.1 (M+1).

出典と根拠

ORDレコード: ord-04699368840d40e9afdc2b45c8a90174
出典データセット: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08293768B2

反応ノート

読み込み中…

参加物