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Ethanol → (Z)-2-Acetylamino-3-dimethylamino-but-2-enoic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | (Z)-4-(1-(Dimethylamino)ethylidene)-2-methyloxazol-5(4H)-one | HCID 67495069 | — |
| 生成物 | (Z)-2-Acetylamino-3-dimethylamino-but-2-enoic acid ethyl ester | HCID 86595898 | — |
反応手順
4-[1-Dimethylamino-eth-(Z)-ylidene]-2-methyl-4H-oxazol-5-one (7.4 g, 44.0 mmol) was dissolved in ethanol (50 ml), and sodium hydride (0.10 g, 4.4 mmol) was added at room temperature. The dark solution was refluxed for 1 h. The solvent was evaporated, and the crude product [MS: m/e=215.5 (M+H+)] was used without any further purification for the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08293916B2 |
| 出典データセット | uspto-grants-2012_10 |
| ORD ID | ord-81f953fea32e40dc8344c7bdb61e680a |
| 出典メモ | uspto-grants-2012_10 |