Hydrochloric Acid → 1-(3-Chloro-4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid

HRID 2067949ノート

反応式

HRID 2067949 の反応式
C([O:5][C:6]([C:8]1[CH:9]=[N:10][N:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[C:16]([Cl:21])[CH:15]=2)[C:12]=1[CH3:13])=[O:7])(C)(C)C.Cl.O1CCOCC1>>[Cl:21][C:16]1[CH:15]=[C:14]([N:11]2[C:12]([CH3:13])=[C:8]([C:6]([OH:7])=[O:5])[CH:9]=[N:10]2)[CH:19]=[CH:18][C:17]=1[F:20]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 584433921-(3-chloro-4-fluoro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid tert-butyl ester

生成物 1

HCID 222279051-(3-Chloro-4-fluorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid収率 31.2%

実験手順

1-(3-Chloro-4-fluoro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid tert-butyl ester (2.1 g, 6.8 mmol) is treated with cold HCl in dioxane (4.0 N solution, 10 mL, 40 mmol) and stirred for 16 hours at room temperature. The resultant precipitate is collected by filtration, washed with dioxane (2×1 mL) and dried to afford 1-(3-chloro-4-fluoro-phenyl)-5-methyl-1H-pyrazole-4-carboxylic acid as a tan solid (540 mg, 31%).

後処理

  1. filtrationThe resultant precipitate is collected by filtration
  2. washwashed with dioxane (2×1 mL)
  3. customdried

出典と根拠

ORDレコード
ord-9c5d521c3304472b9695ab51980b7ccb
出典データセット
uspto-grants-2012_10
特許番号
US08293917B2

反応ノート

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