Hydrochloric Acid → 1-(5-Bromo-pyridin-3-yl)-butylamine
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([NH:12]S(C(C)(C)C)=O)[CH2:9][CH2:10][CH3:11])[CH:5]=[N:6][CH:7]=1.Cl>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]([NH2:12])[CH2:9][CH2:10][CH3:11])[CH:5]=[N:6][CH:7]=1参加物
3
実験手順
2-Methyl-propane-2-sulfinic acid 1-(5-bromo-pyridin-3-yl)-butylamide (16 g, 48 mmol) is treated with aqueous HCl (3.0 N solution, 400 mL, 1.2 mol) at room temperature and stirred for 5 hours. The reaction mixture is quenched by addition of saturated aqueous sodium carbonate solution until pH 8 and extracted with dichloromethane (3×300 mL). The combined organic phases are dried over Na2SO4, filtered, and concentrated to afford 1-(5-bromo-pyridin-3-yl)-butylamine (9.5 g, 86%) of as a light brown oil.
後処理
- customThe reaction mixture is quenched by addition of saturated aqueous sodium carbonate solution until pH 8
- extractionextracted with dichloromethane (3×300 mL)
- dry with materialThe combined organic phases are dried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-a537609bc38f44a3875115e7ca624209
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08293917B2
反応ノート
読み込み中…