Trimethylsilyldiazomethane → HCID 43147866、化合物
反応式
[NH2:1][CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Br:13])[CH:8]=1)[CH2:3][C:4]([OH:6])=[O:5].[CH3:14][Si](C=[N+]=[N-])(C)C>>[CH3:14][O:5][C:4](=[O:6])[CH2:3][CH:2]([NH2:1])[C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Br:13])[CH:8]=1参加物
3
実験手順
To a solution of 3-amino-3-(3-bromo-phenyl)-propionic acid (1.0 g, 4.1 mmol) in methanol-toluene (100 mL; 1:1 solution) at room temperature is added trimethylsilyl diazomethane (2.0 M solution in hexanes, 20 mL, 40 mmol). After 30 min, excess trimethylsilyl diazomethane is quenched by addition of glacial acetic acid (5 mL). Concentration in vacuo affords of 3-amino-3-(3-bromo-phenyl)-propionic acid methyl ester (1.0 g, 95%) as a colorless liquid which solidifies upon standing.
後処理
- customexcess trimethylsilyl diazomethane is quenched by addition of glacial acetic acid (5 mL)
- concentrationConcentration in vacuo
出典と根拠
- ORDレコード
- ord-6469d99b38774976955b57419cf219c2
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08293917B2
反応ノート
読み込み中…