3-(3-Benzyloxypropyl)imidazolidine-2,4-dione → 3-(3-Hydroxypropyl)imidazolidine-2,4-dione
反応式
C([O:8][CH2:9][CH2:10][CH2:11][N:12]1[C:16](=[O:17])[CH2:15][NH:14][C:13]1=[O:18])C1C=CC=CC=1>CO>[OH:8][CH2:9][CH2:10][CH2:11][N:12]1[C:16](=[O:17])[CH2:15][NH:14][C:13]1=[O:18]参加物
3
実験手順
3-(3-Benzyloxypropyl)imidazolidine-2,4-dione (1.3 g, 5.26 mmol) was dissolved in methanol (15 ml) and the system purged with nitrogen. 10% Palladium on carbon (130 mg, 10% by mass) and a few drops of glacial acetic acid were added and the mixture stirred under a hydrogen atmosphere (1 atmosphere) for 3 days. The mixture was filtered and concentrated under reduced pressure. The residue was purified by column chromatography eluting with methylene chloride/methanol (98/2 to 95/5) to give 3-(3-hydroxypropyl)imidazolidine-2,4-dione (606 mg, 73%) as a viscous oil which crystallised on standing.
後処理
- customthe system purged with nitrogen
- addition10% Palladium on carbon (130 mg, 10% by mass) and a few drops of glacial acetic acid were added
- filtrationThe mixture was filtered
- concentrationconcentrated under reduced pressure
- customThe residue was purified by column chromatography
- washeluting with methylene chloride/methanol (98/2 to 95/5)
出典と根拠
- ORDレコード
- ord-13213b873ee44ca1b57a337fdc077e67
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08293902B2
反応ノート
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