SK&F 81297 → Dopamine

HRID 2068455

反応式

HRID 2068455 の反応式
CCCN1[C@@H]2CC3C4C(=CC=CC=4NC=3)[C@H]2C[C@@H](CSC)C1.C1[C:33]2[C:28](=[CH:29][C:30]([OH:36])=[C:31]([OH:35])[C:32]=2Cl)[CH:27](C2C=CC=CC=2)[CH2:26][NH:25]C1>>[NH2:25][CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31]([OH:35])=[C:30]([OH:36])[CH:29]=1

参加物

3

反応物 2

HCID 1218SK&F 81297HCID 47811Pergolide

生成物 1

HCID 681Dopamine

実験手順

HEK cells were transfected with a DNA construct encoding D1-NLS-GFP (1.5 micrograms of DNA), and incubated with the agonist pergolide (10 micromolar) for 48 hours. At 6, 22, 30 and 42 hours after transfection, the cells were treated with fresh medium containing SKF-81297 (final concentration 10 micromolar). The cells were examined by confocal microscopy.

後処理

  1. additionAt 6, 22, 30 and 42 hours after transfection, the cells were treated with fresh medium

出典と根拠

ORDレコード
ord-688973ee7bcc4281899a9883ffcfc926
出典データセット
uspto-grants-2012_10
特許番号
US08298777B2

関連ノート

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