Hydrochloric Acid → 2-Amino-5-bromobenzoic acid

HRID 2068586

反応式

HRID 2068586 の反応式
C([NH:4][C:5]1[C:6](=[CH:10][C:11]([Br:14])=[CH:12][CH:13]=1)[C:7]([OH:9])=[O:8])(=O)C.Cl>O1CCOCC1>[Br:14][C:11]1[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([NH2:4])=[CH:13][CH:12]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 5209352-Acetamido-5-bromobenzoic Acid

生成物 1

HCID 798582-Amino-5-bromobenzoic acid収率 91.7%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
110 °C

実験手順

To a mixture of 9 (71 g, 0.275 mol) in 1,4-dioxane (400 mL) was added HCl (400 mL). The mixture was refluxed for 4 h at 110° C. Then the mixture was concentrated and added to 300 mL water. The mixture was filtered and the pH was adjusted to 6 with 2N NaOH, washed with water and dried to give 10 as a white solid (54.5 g, yield: 91.7%).

後処理

  1. concentrationThen the mixture was concentrated
  2. additionadded to 300 mL water
  3. filtrationThe mixture was filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-fa5d04b685f14e48a922b9a0d012d30c
出典データセット
uspto-grants-2012_10
特許番号
US08299023B2

関連ノート

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