Water → 7-Bromo-2-(2-hydroxyethyl)-isoquinolin-1-one
反応式
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][NH:8][C:9]2=[O:12])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:20][CH2:21][OH:22].O>CN(C)C=O>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][N:8]([CH2:20][CH2:21][OH:22])[C:9]2=[O:12])=[CH:4][CH:3]=1参加物
6
実験手順
A solution of compound 5 (19.8 g, 88.4 mmol), potassium carbonate (18.3 g, 133 mmol) and 2-bromoethanol (13.3 g, 106 mmol) in dimethylforamide (200 mL) was stirred at 80° C. for 12 h. Then the mixture was cooled to room temperature and poured into water. The mixture was extracted with ethyl acetate (three times 500 mL), dried (sodium sulfate), concentrated and purified by chromatography on silica gel to give 6 (16.2 g, 68%)
後処理
- extractionThe mixture was extracted with ethyl acetate (three times 500 mL)
- dry with materialdried (sodium sulfate)
- concentrationconcentrated
- custompurified by chromatography on silica gel
出典と根拠
- ORDレコード
- ord-a2dd00f879784a5797fb0676e3ae4eac
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08299023B2
反応ノート
読み込み中…