化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Hydroxide → 5-Oxazol-4-yl-thiophene-3-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 5-Oxazol-4-yl-thiophene-3-carboxylic acid methyl ester | HCID 58110244 | — |
| 生成物 | 5-Oxazol-4-yl-thiophene-3-carboxylic acid | HCID 58110221 | 100.2% |
反応手順
5-Oxazol-4-yl-thiophene-3-carboxylic acid methyl ester (0.049 g, 0.23 mmol) was suspended in IMS (1 mL), sodium hydroxide (1 M, 0.35 mL) was added and the mixture stirred for 60 hours at room temperature. The mixture was quenched with HCl (1 N, 0.35 mL) and then concentrated, azeotroping twice with methanol to afford 5-oxazol-4-yl-thiophene-3-carboxylic acid as a white solid (0.045 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08299063B2 |
| 出典データセット | uspto-grants-2012_10 |
| ORD ID | ord-a9e15b923af248999376c9b186edc511 |
| 出典メモ | uspto-grants-2012_10 |