benzyl (S)-2-(morpholin-4-yl)propionate → (S)-2-Morpholin-4-yl-propionic acid

HRID 2068868ノート

反応式

HRID 2068868 の反応式
[N:1]1([C@@H:7]([CH3:18])[C:8]([O:10]CC2C=CC=CC=2)=[O:9])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1>CO.[OH-].[Pd+2].[OH-].[C]>[N:1]1([C@@H:7]([CH3:18])[C:8]([OH:10])=[O:9])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

参加物

4

反応物 1

HCID 13765076benzyl (S)-2-(morpholin-4-yl)propionate

生成物 1

HCID 7059243(S)-2-Morpholin-4-yl-propionic acid収率 93%

試薬・触媒・溶媒 2

HCID 178502593HCID 178502593、化合物触媒HCID 887Methanol溶媒

実験手順

Under an argon atmosphere, to a solution of benzyl (S)-2-(morpholin-4-yl)propionate (43 g, 172 mmol) in methanol (430 ml) was added 20% palladium hydroxide-carbon (4.3 g) at room temperature, and the mixture was stirred for 3 hr under a hydrogen atmosphere at normal pressure. The reaction mixture was filtered through celite, and the filtrate was concentrated under reduced pressure to give the title compound (25.4 g, 93%).

後処理

  1. filtrationThe reaction mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-197a64d754284167a55ef50e8ed5f55a
出典データセット
uspto-grants-2012_10
特許番号
US08299070B2

反応ノート

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