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Tryptophanol → N-{6-[2-Hydroxy-1-(1H-indol-3-ylmethyl)-ethylamino]-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-methanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tryptophanol | HCID 10684 | — |
| 反応物 | N-(6-fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide | HCID 58964482 | — |
| 生成物 | N-{6-[2-Hydroxy-1-(1H-indol-3-ylmethyl)-ethylamino]-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl}-methanesulfonamide | HCID 69338521 | 33% |
反応手順
N-(6-Fluoro-7-nitro-2,4-dioxo-1,4-dihydro-2H-quinazolin-3-yl)-methanesulfonamide (30 mg, 0.0943 mmol) is reacted with 2-amino-3-(1H-indol-3-yl)-propan-1-ol according to the GPA affording 18.8 mg (33%) of a red powder. Rt=4.27 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08299085B2 |
| 出典データセット | uspto-grants-2012_10 |
| ORD ID | ord-d4b6ac52149341c2b60af9bf4a1f1680 |
| 出典メモ | uspto-grants-2012_10 |