2-Nitro-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester → 2-Amino-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester

HRID 2069270ノート

反応式

HRID 2069270 の反応式
[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][S:13][CH2:12][CH2:11]2)[C:7]([C:16]([F:19])([F:18])[F:17])=[CH:6][C:5]=1[N+:20]([O-])=O>C(O)C.[Ni]>[CH3:1][O:2][C:3](=[O:23])[C:4]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][S:13][CH2:12][CH2:11]2)[C:7]([C:16]([F:17])([F:18])[F:19])=[CH:6][C:5]=1[NH2:20]

参加物

4

反応物 1

HCID 589645312-Nitro-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester

生成物 1

HCID 589645242-Amino-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester収率 84.9%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

300 mg of 2-nitro-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester in 10 ml of dry ethanol are hydrogenated in presence of 60 mg of Raney nickel, After filtration of the catalyst the solution is evaporated to dryness yielding 233 mg of 2-amino-5-thiomorpholin-4-yl-4-trifluoromethyl-benzoic acid methyl ester as yellow powder, m.p. 85-117° C. (decomp.).

後処理

  1. filtrationAfter filtration of the catalyst the solution
  2. customis evaporated to dryness

出典と根拠

ORDレコード
ord-991edd439a7e471bbb5257abb2cef030
出典データセット
uspto-grants-2012_10
特許番号
US08299085B2

反応ノート

読み込み中…