Ammonia → 2-Isopropylamino-6-methyl-pyrimidine-4-carboxylic acid amide
反応式
C([O:3][C:4]([C:6]1[CH:11]=[C:10]([CH3:12])[N:9]=[C:8]([NH:13][CH:14]([CH3:16])[CH3:15])[N:7]=1)=O)C.[NH3:17]>CO>[CH:14]([NH:13][C:8]1[N:7]=[C:6]([C:4]([NH2:17])=[O:3])[CH:11]=[C:10]([CH3:12])[N:9]=1)([CH3:16])[CH3:15]参加物
4
実験手順
A solution of 2-isopropylamino-6-methyl-pyrimidine-4-carboxylic acid ethyl ester (1.46 g, 6.54 mmol) in 3M NH3 in MeOH (50 mL) is stirred at 60° C. for 1 day. Volatiles are evaporated to give the crude 2-isopropylamino-6-methyl-pyrimidine-4-carboxylic acid amide as a pale yellow solid (1.24 g); LC-MS: tR=0.59; [M+H]+=195.0.
後処理
- customVolatiles are evaporated
出典と根拠
- ORDレコード
- ord-ab345cbea5eb4d10af3ac3468cf4ac7b
- 出典データセット
- uspto-grants-2012_10
- 特許番号
- US08299086B2
反応ノート
読み込み中…