2-(Ethylamino)-6-methylpyrimidine-4-carboxylic acid → HCID 68506088、化合物

反応式

[CH2:1]([NH:3][C:4]1[N:9]=[C:8]([C:10]([OH:12])=O)[CH:7]=[C:6]([CH3:13])[N:5]=1)[CH3:2].[CH3:14][C:15]1([CH3:34])[O:19][CH:18]([CH2:20][O:21][C:22]2[C:31]([CH3:32])=[CH:30][C:25]([C:26]([NH:28]O)=[NH:27])=[CH:24][C:23]=2[CH3:33])[CH2:17][O:16]1>>[CH3:14][C:15]1([CH3:34])[O:19][CH:18]([CH2:20][O:21][C:22]2[C:23]([CH3:33])=[CH:24][C:25]([C:26]3[N:28]=[C:10]([C:8]4[CH:7]=[C:6]([CH3:13])[N:5]=[C:4]([NH:3][CH2:1][CH3:2])[N:9]=4)[O:12][N:27]=3)=[CH:30][C:31]=2[CH3:32])[CH2:17][O:16]1

参加物

反応物 2

HCID 552957042-(Ethylamino)-6-methylpyrimidine-4-carboxylic acid

HCID 178426655HCID 178426655、化合物

生成物 1

HCID 68506088HCID 68506088、化合物

実験手順

2-Ethylamino-6-methyl-pyrimidine-4-carboxylic acid and 4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-N-hydroxy-3,5-dimethyl-benzamidine are coupled followed by cyclisation in analogy to Example 1 to give (4-{3-[4-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-3,5-dimethyl-phenyl]-[1,2,4]-oxadiazol-5-yl}-6-methyl-pyrimidin-2-yl)-ethyl-amine; LC-MS: tR=1.12 min; [M+H]+=440.21.

出典と根拠

ORDレコード: ord-67ad0ba38e1145c7bc846c60af887620
出典データセット: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08299086B2

反応ノート

読み込み中…

参加物