Dimethylamine → 4-(3,5-dichloropyridin-4-ylamino)-8-(7-(dimethylamino)heptyloxy)-7-methoxy-2H-chromen-2-one
反応式
[CH3:1][NH:2][CH3:3].Br[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]Br.[Cl:13][C:14]1[CH:15]=[N:16][CH:17]=[C:18]([Cl:35])[C:19]=1[NH:20][C:21]1[C:30]2[C:25](=[C:26]([OH:33])[C:27]([O:31][CH3:32])=[CH:28][CH:29]=2)[O:24][C:23](=[O:34])[CH:22]=1>>[Cl:13][C:14]1[CH:15]=[N:16][CH:17]=[C:18]([Cl:35])[C:19]=1[NH:20][C:21]1[C:30]2[C:25](=[C:26]([O:33][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][N:2]([CH3:3])[CH3:1])[C:27]([O:31][CH3:32])=[CH:28][CH:29]=2)[O:24][C:23](=[O:34])[CH:22]=1参加物
4
実験手順
The title compound was prepared from dimethylamine, 1,7-dibromoheptane, and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedures outlined in Examples 25 & 27. 1H NMR (400 MHz, DMSO-d6): δ 9.38 (br s, 1H), 8.58 (s, 2H), 7.85 (d, 1H), 7.05 (d, 1H), 4.26 (br s, 1H), 3.96 (t, 2H), 3.87 (s, 3H), 2.51 (br, 2H), 2.35 (s, 6H), 1.67 (m, 2H), 1.46 (m, 4H), 1.30 (m, 4H); MS (ESI): 493.9.